en بیوشیمی Biochemistry Research Article Research Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Type 2 diabetes mellitus (T2DM) is a serious chronic disease associated with hyperglycemia, overweight, and metabolic syndrome. The prevalence of this disease is constantly increasing. This study aimed to investigate the separate and combined effects of resistance training and cucumber juice consumption on liver indicators in women with T2DM.<br> <b>Methods:</b> Females aged 35-70 years (N = 40) suffering from T2DM were selected. The subjects were randomly assigned to four groups (three experimental groups and one control group). The Training+ placebo group implemented resistance training and consumed a placebo. The Training+ Supplement group implemented resistance training and consumed cucumber juice, the Supplement group consumed cucumber juice, while the control group consumed a placebo for eight weeks. 48 hours before and after the research, blood sampling was done, and changes in liver enzyme levels were investigated and compared among the groups. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey&rsquo;s post-hoc test at a significance level of p &le; 0.05.<br> <b>Results:</b> The results of the present study showed that eight weeks of separate or combined resistance training and consumption of cucumber juice led to a significant reduction in the levels of liver enzymes Alanine transaminase (ALT), Aspartate transaminase (AST), and Alkaline phosphatase (ALP) (p &le; 0.05).<br> <b>Conclusion</b>: In the present study, liver enzyme levels decreased. Therefore, separate or combined implementation of resistance training and consumption of cucumber juice can be used as therapeutic aids to control the levels of liver enzymes in women with T2DM.</span></span><br> &nbsp;</div> Education, Diabetes Mellitus, Type 2, Cucumber juice 27 30 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1728-1&slc_lang=en&sid=1 Maryam Lotfi maryam.l.8432@gmail.com 100319475328460031337 100319475328460031337 No Department of Exercise Physiology, Razi University, Kermanshah, Iran Nasser Behpoor n_behpoor@yahoo.com 100319475328460031338 100319475328460031338 Yes Department of Exercise Physiology, Razi University, Kermanshah, Iran Mehrali Rahimi mjavadra@yahoo.com 100319475328460031339 100319475328460031339 No Diabetes Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Afshar Jafari afshar.jafari@gmail.com 100319475328460031340 100319475328460031340 No Department of Biological Sciences in Sport, Shahid Beheshti University of Medical Sciences, Tehran, Iran