fa شیوع بتالاکتامازهای وسیع الطیف (ESBLs) و الگوی مقاومت آنتی بیوتیکی سویه های اسینتوباکتر بومانی جداشده از نمونه های بالینی شهر اصفهان تحقيقي Original Paper <div> <p><strong>Abstract</strong></p> <p><strong>Background and Objective: </strong><em>Acinetobacter</em> species are opportunistic important pathogens responsible for many nosocomial infections. The purpose of this study was to determine the drug resistan pattern <em>Acinetobacter baumannii</em> and prevalence of ESBL producing strains in Intensive Care Unit patients in Isfahan city hospitals.</p> <p></p> <p><strong>Material and Methods: </strong>The study was conducted on 100 <em>Acinetobacter baumannii</em> strains isolated from clinical samples.&nbsp; The Isolates were identified by standard methods and confirmed by PCR method. Drug resistance pattern of isolates was determined by standard disk diffusion method according to CLSI. To identify ESBL producing strains, a Combined Disk phenotypic method was used.</p> <p></p> <p><strong>Results:</strong> Hundred percent of <em>Acinetobacter baumannii</em> strains was MDR and the maximum antibiotics resistance was shown to cefepime, co<span dir="rtl">-</span>trimoxazole, ciprofloxacin, meropenem and ceftazidime. According to initial screening, 4.5% of strains were producing Extended Spectrum Beta Lactamase enzyme.</p> <p></p> <p><strong>Conclusion:</strong> The percent of ESBLs producing strains is low. Thus, Combined Disk for initial screening of ESBLs strains and multiplex PCR for rapid detection of ESBLs strains are recommended.&nbsp;&nbsp; This issue can be a new step in preventing from the spread of Acinetobacter Baumannii Strains in hospitals particularly in intensive care unit.</p> <p></p> <p><strong>Keywords:</strong> <a href="http://www.ncbi.nlm.nih.gov/mesh/68001618">Beta-Lactamases</a>; Acinetobacter Baumannii; Drug Resistance</p> </div> Beta-Lactamases, Acinetobacter Baumannii, Drug Resistance . 32 39 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-333&slc_lang=fa&sid=1 J Vazirzadeh ژیناوزیرزاده 100319475328460012899 100319475328460012899 No Shariati Security organization Hospital, Isfahan, Iran بیمارستان تأمین اجتماعی شریعتی اصفهان، ایران H Ghajavand حسن قجاوند 100319475328460012900 100319475328460012900 No Shariati Security Organization Hospital Isfahan, Iran بیمارستان تأمین اجتماعی شریعتی اصفهان، ایران L Heidari لیلا حیدری 100319475328460012901 100319475328460012901 No Shariati Security Organization Hospital Isfahan, Iran بیمارستان تأمین اجتماعی شریعتی اصفهان، ایران P Behshood پریسا بهشود 100319475328460012902 100319475328460012902 Yes Falavarjan Branch, Islamic Azad University, Isfahan, Iran دانشگاه آزاد اسلامی، واحد فلاورجان، باشگاه پژوهشگران جوان و نخبگان، اصفهان