en فیزیولوژی ورزشی Sport Physiology Research Article Research Article <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:12px;"><b>Background:</b> Running and starvation can have a positive effect on the reticulophagy of the liver tissue. The purpose of this research was to investigate the effect of running and starvation interventions on the atherogenic index and Xbp1 gene change in the liver endoplasmic reticulum of non-alcoholic fatty liver rats (NAFLD).<br> <b>Methods:</b> Thirty obese male Wistar rats aged 18-20 weeks with an average body weight of 348 &plusmn; 25.53 grams, after one week of familiarization with the laboratory environment, were randomly divided into six groups (n=5 per group): 1) starvation, 2) three days of training, 3) five days of training, 4) three days of training plus starvation, 5) five days of training plus starvation, and 6) the control group. All fatty liver animal models had free access to water and standard food pellets (10 gr per 100 g of mouse body weight). The statistical test of one-way analysis of variance was used at a significance level of less than 0.05, and the LSD post-hoc test was used to compare research groups.<br> <b>Results:</b> According to the experimental results and statistical analyses (One-way analysis of variance), a significant decrease was noticed in the ratio of lipoproteins (VLDL/HDL and LDL/HDL) in all experimental groups compared to the control group. Also, a significant decrease was observed in the expression of XBP1 and CHOP genes in animals doing 3 and 5 days of exercise alone or along with starvation.<br> <b>Conclusion</b>: Regular exercise for 3 and 5 days per week with starvation can possibly reduce the activity of the genes involved in endoplasmic reticulum stress in NAFLD patients.</span></span><br> &nbsp;</div> Transcription Factor CHOP, Exercise, Endoplasmic Reticulum, Starvation, Xbp1 protein, Xenopus 19 23 http://mlj.goums.ac.ir/browse.php?a_code=A-10-702-3&slc_lang=en&sid=1 Mahshad Paziraee mahshad.pazirayi@gmail.com 100319475328460029411 0009-0003-2993-7286 No Department of Physical Education and Sports Sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran Habib Asgharpour Habib.asgharpour@gmail.com 100319475328460029412 100319475328460029412 Yes Department of Physical Education and Sports Sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran Asra Askari askari.asra@gmail.com 100319475328460029413 100319475328460029413 No Department of Physical Education and Sports Sciences, Gorgan Branch, Islamic Azad University, Gorgan, Iran Reza Rezaei Shirazi rezaii725@yahoo.com 100319475328460029414 100319475328460029414 No Department of Physical Education and Sports Sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran Neda Aghaei Bahman Beglo nedaaghaei@gmail.com 100319475328460029415 100319475328460029415 No Department of Physical Education and Sports Sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran