en ژنتیک انسانی Human Genetics مروري Review Article Coma&nbsp;is a state of prolonged <a href="https://en.wikipedia.org/wiki/Unconsciousness" title="Unconsciousness">unconsciousness</a>. Some coma cases result from inherited disorders such as fatty-acid &beta;-oxidation disorder, acute intermittent porphyria (due to mutations in genes <em>CPT I, CPT</em><em>II </em>and<em> ACADM</em>), urea cycle defects (due to mutation in <em>OTC</em> gene), organic acidurias, mitochondrial diseases and familial hemiplegic migraine (due to mutations in <em>CACNA1A, ATP1A2 </em>and<em> SCN1A</em>). The evaluation of familial cases of coma or sporadic coma can be performed using next generation sequencing (NGS), a <a href="https://www.ncbi.nlm.nih.gov/mesh/68059014">high-throughput </a>&nbsp;sequencing technique that can sequence an entire genome in a single reaction. This technique has been widely applied in the genetic diagnosis of diseases. In this review, we describe some genes associated with coma or recurrent coma and discuss the role of NGS in detection of these genes. &nbsp; Coma,High-Throughput Nucleotide Sequencing,Genes, 1 8 http://mlj.goums.ac.ir/browse.php?a_code=A-10-992-1&slc_lang=en&sid=1 fatemeh asadi fatemehasadi@maiu.ac.ir 100319475328460021541 100319475328460021541 No PhD student, Department of Genetics, Fars Science and Research Branch, Islamic Azad University, Marvdasht, Iran And Department of Genetics, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran hamedreza goodarzi drgoodarzi.lab@gmail.com 100319475328460021542 100319475328460021542 Yes Department of Genetics, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran javad zahiri zahiri@modares.ac.ir 100319475328460021543 100319475328460021543 No Department of Bioinformatics, Faculty of Biology Sciences, Tarbiat Modares University, Tehran, Iran mojtaba jafarinia m.jafarinia@miau.ac.ir 100319475328460021544 100319475328460021544 No Department of Genetics, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran