fa ژنتیک انسانی Human Genetics تحقيقي Original Paper <div><strong>ABSTRACT</strong><br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background and Objectives: </strong>Diabetes is one of the most common diseases and a major risk factor for cardiovascular disease. Studies have shown that regular exercise can affect apoptosis in cardiomyocytes. The purpose of this study was to investigate the effect of high-intensity interval training on the expression of Bcl-2 and Bax as important apoptosis factors in diabetic rats.<span dir="RTL"></span><br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <strong>Methods</strong>: After inducing diabetes in 20 male Wistar rats (weighing 250 &plusmn; 1.15 g), the rats were randomly divided into a control group and a training group. The training group performed high-intensity interval training five days a week for four weeks, and the control group did not perform any training. After the intervention, RNA was extracted and TCF mRNA was subjected to real time RT-PCR for measuring Bax and Bcl-2 expression in the heart tissue of diabetic rats. Data were analyzed by IBM SPSS Statistics V22 using independent t-test. P-values less than 0.05 were considered as statistically significant.<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <strong>Results</strong>: The expression of Bcl-2 increased significantly and the expression of Bax decreased significantly after the four-week training intervention.<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <strong>Conclusion:</strong> The high-intensity interval training can have beneficial effects on the expression of apoptotic genes in rats with type 2 diabetes.<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <strong>Keywords:</strong> Bax, Bcl-2, High intensity interval training, Heart, Type 2 diabetes.</div> Bax, Bcl-2, High intensity interval training, Heart, Type 2 diabetes. 15 20 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-555&slc_lang=fa&sid=1 Nasrin Ramezani 100319475328460014962 100319475328460014962 Yes Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Tehran University, Tehran, Iran Behnaz Vanaky Bv73ir@yahoo.com 100319475328460014963 100319475328460014963 No Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran Nader Shakeri 100319475328460014964 100319475328460014964 No Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran Zahra Soltanian 100319475328460014965 100319475328460014965 No Department of Sport Physiology, Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran Fatemeh Fakhari Rad 100319475328460014966 100319475328460014966 No Department of Sport Physiology, Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran Zahra Shams 100319475328460014967 100319475328460014967 No Department of Sport Physiology, Faculty of Physical Education and Sports science, Central Tehran Branch, Islamic Azad University, Tehran, Iran