fa تحقيقي Original Paper <div><strong>ABSTRACT</strong><br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background and objectives: </strong>The aim of this study was to investigate the effects of six months of aerobic exercise on lipid profile, inflammatory markers, and risk factors of cardiovascular disease in middle-aged obese women.<br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Methods: </strong>Fifteen obese woman (age range: 35 to 45 years) with BMI of &ge;30 Kg/m² were enrolled via purposeful and convenience sampling. The participants were randomly divided into training (n=10) and control (n=5) groups.&nbsp; Blood samples (7 ml) were taken from all participants before the first training session and after the last training session. The women performed 60 minutes of aerobic exercise at 55-65% of heart rate reserve, three sessions a week, for six months. Data was analyzed using independent and paired t-tests and Mann-Whitney U and Wilcoxon tests at significance of 0.05.<br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Results:</strong> After the six-month aerobic exercise, C-reactive protein, low-density lipoprotein, triglycerides, total cholesterol and high-density lipoprotein/total cholesterol decreased significantly. The exercise intervention also caused a significant increase in the concentrations of high-density lipoprotein and apolipoprotein A.<br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Conclusion:</strong> Aerobic exercise can reduce the level of inflammatory markers associated with risk of cardiovascular disease and atherosclerosis.<br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Keywords:</strong> Lipid profile, Inflammatory markers, Obese women, Apolipoprotein, Aerobic exercise.</div> Lipid profile, Inflammatory markers, Obese women, Apolipoprotein, Aerobic exercise. 32 37 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-512&slc_lang=fa&sid=1 Mahtab Moazzami Mahtab.moazami@gmail.com 100319475328460014222 0000000264222935 Yes Department of Exercise Physiology, Faculty of Physical Education & Sport Science, Ferdowsi University of Mashhad, Mashhad, Iran Asra Askari 100319475328460014223 100319475328460014223 No Department of physical education & Sport Science, Gorgan Branch, Islamic Azad University, Gorgan, Iran