fa تحقيقي Original Paper <div>ABSTRACT <h1><a name="_Toc416081061">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Background and Objectives: </a>Sirtuin (SIRT), Fibroblast Growth Factor₂₁ (FGF₂₁) and Fetuin A are proteins that cause a wide range of metabolic disorders such as type 2 diabetes mellitus (T2DM). On the other hand, regular physical activity is known to play a key role in prevention and management of T2DM. Thus, this study investigated the effect of vigorous aerobic exercise on serum levels of metabolic parameters including SIRT₁, FGF₂₁and Fetuin A in women with T2DM.</h1> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Methods: </strong>The study was performed on 28 randomly selected women with T2DM who were divided into an exercise group and a control group. The training intervention consisted eight weeks of vigorous aerobic exercise (three times a week at 70-80% of maximum heart rate). The serum levels of SIRT₁, FGF₂₁ and Fetuin A were evaluated before the first session and 48 hours after the last session. Paired sample t-test and independent t-test were used to analyze within and between group differences, respectively. All statistical analyses were performed in SPSS (version 19) at significance of 0.05.<br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Results: </strong>The eight-week aerobic training caused a significant reduction in body weight, body mass index, insulin resistance, low-density lipoprotein, fasting blood sugar, triglycerides and Fetuin A of women with T2DM. In addition, it caused a significant increase in SIRT1 and FGF₂₁ levels. There was no significant difference in the level of high-density lipoprotein and cholesterol between the two groups.<br> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <strong>Conclusion</strong><strong>:</strong> As a non-pharmacological therapy, regular aerobic exercise might improve the metabolic parameters, SIRT1, FGF21, and Fetuin A in women with T2DM.<br> <strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Keywords:</strong> <a href="https://www.ncbi.nlm.nih.gov/mesh/68003924">Diabetes Mellitus Type 2</a>, SIRT₁, FGF₂₁, Fetuin A, Exercise.</div> Diabetes Mellitus Type 2, SIRT1, FGF21, Fetuin A, Exercise. 1 6 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-507&slc_lang=fa&sid=1 Exir Vizvari 100319475328460014196 100319475328460014196 No Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran. Parvin Farzanegi 100319475328460014197 0000000321283068 Yes Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran Hajar Abbas Zade Sourati 100319475328460014198 100319475328460014198 No Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran