Medical Laboratory Journal
Medical Laboratory Journal
mljgoums
Medical Sciences
http://mlj.goums.ac.ir
1
admin
2538-4449
10.66224/mlj
en
jalali
1396
6
1
gregorian
2017
9
1
11
5
online
1
fulltext
fa
Anti-Leishmanial Activity of Pelargonium roseum Essential Oil on Growth of Leishmania infantum Promastigotes
تحقيقي
Original Paper
<div><strong>ABSTRACT</strong><br>
<strong> Background and Objectives:</strong> Due to adverse effects of pentavalent antimonial treatment of visceral leishmaniasis using herbal medicines has received a lot of attention. In this study, we evaluated inhibitory activity of <em>Pelargonium roseum</em> essential oil on growth of <em>Leishmania infantum </em>promastigotes, and compared it with that of Glucantime.<br>
<strong> Methods</strong><strong>:</strong> Inhibitory effects of different concentrations (1, 2.5, 5, 10, 25, 50 and 100 µL/ml) of <em>P. roseum</em> essential oil on the growth of <em>L. infantum </em>promastigotes were studied by MTT assay after 24 and 48 hours. All the data were analyzed by one-way analysis of variance. The effect of the essential oil was later compared with that of standard dose of Glucantime.<br>
<strong> Results</strong>: After 24 hours, different concentrations of the essential oil had no significant inhibitory effect on promastigotes of <em>L. infantum</em>. After 48 hours, all concentrations except for 1µL/ml showed significant anti-leishmanial activity. In addition, the lowest concentration that had significant inhibitory effect on <em>L. infantum</em> promastigote was 5 µL/ml.<br>
<strong> Conclusion</strong>: The essential oil of <em>P. roseum</em> has favorable inhibitory activity on the growth of <em>L. infantum</em> promastigotes after 48 hours. This indicates the therapeutic potential of this plant for treatment of leishmaniasis.<br>
<strong> Keywords:</strong> <em>Leishmania infantum</em>, <em>Pelargonium</em>, Promastigote, Meglumine antimoniate.</div>
Leishmania infantum, Pelargonium, Promastigote, Meglumine antimoniate.
36
40
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-476&slc_lang=fa&sid=1
Mohaddeseh
Abouhosseini Tabari
100319475328460013904
100319475328460013904
No
Faculty of Veterinary Medicine, Amol University of Special ModernTechnologies, Amol, Iran
Mohammad Reza
Youssefi
100319475328460013905
100319475328460013905
No
Department of Veterinary Parasitology, Babol-Branch, Islamic Azad University, Babol, Iran
Bibi Razieh
Hosseini Farash
100319475328460013906
100319475328460013906
No
Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Amin
Ebrahimi
100319475328460013907
100319475328460013907
No
Young Researcher and Elite Club, Babol -Branch,Islamic Azad University, Babol-Branch, Babol, Iran
Niki
Nabavi Mousavi
100319475328460013908
100319475328460013908
No
Young Researcher and Elite Club, Babol- Branch, Islamic Azad University, Babol-Branch, Babol, Iran
Elham
Moghaddas
moghaddase@mums.ac.ir
100319475328460013909
100319475328460013909
Yes
Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran